Engineered reprogramming factors for iPSC generation
A series of engineered molecules that retain a highly specific ability to reprogram adult or fully differentiated cells into pluripotent stem cells only.
QUOTE No: TEC1104133
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The discovery that human adult cells can be reprogrammed to become pluripotent cells with the potential to produce all cell types in the body is a major scientific achievement.
Advantageously, the generation of induced pluripotent stem cells avoids the use of embryonic stem cells. However, reprogramming adult cells is a highly inefficient process that can lead to the generation of other unrelated lineages, such as neurons, as well as producing extra-embryonic trophoblast.
We have identified novel reprogramming factors that are smaller in size than wild-type factors and which can convert differentiated or somatic cells into cells with pluripotent potential. The factors are highly specific for reprogramming and only generate pluripotent stem cells.
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Paul Clarke
Senior Technology Transfer Manager
Paul Clarke bio
Paul Clarke
Senior Technology Transfer Manager
